… protein A inhibits the degradation of caspase-1 to regulate NLRP3 inflammasome activation and exacerbate the Acinetobacter baumannii pulmonary inflammation

Y Li, C Peng, D Zhao, L Liu, B Guo, M Shi, Y Xiao… - Microbial …, 2021 - Elsevier
… As the innate immune system is the first line of host defence … caused by ompA-mediated
release of ROS activates the NLRP3baumannii infection leads to activation of the NLRP3

Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii

G Burgio, FJ Li, L Starrs, A Mathur, DE Tuipulotu… - 2024 - researchsquare.com
baumannii 19 activate the NLRP3 inflammasome complex … of the pro- 62 inflammatory
cytokines pro-interleukin- (pro-IL-… the 260 contribution of type I IFN signalling to inflammasome

GBP1 promotes killing of multidrug-resistant Acinetobacter baumannii and promotes host protection via interferon signalling and inflammasome activation

FJ Li, L Starrs, A Mathur, D Enosi Tuipulotu, SM Man… - bioRxiv, 2022 - biorxiv.org
baumannii activate the NLRP3 inflammasome complex … cleavage of the pro-inflammatory
cytokines pro-interleukin- (pro-IL-1β) … recruitment in Nlrp3 -/- mice might have contributed to …

[HTML][HTML] Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264. 7 …

Z An, J Su - Microbes and Infection, 2019 - Elsevier
… pyroptosis by NLRP3 inflammasome-mediated IL-1β … baumannii-caused pulmonary damage
in mice with NLRP3, … release, which leads to pyroptosis of RAW264.7 cells. We thought that …

OmpA Protein-Deficient Acinetobacter baumannii Outer Membrane Vesicles Trigger Reduced Inflammatory Response

J Skerniškytė, E Karazijaitė, A Lučiūnaitė… - Pathogens, 2021 - mdpi.com
baumannii OMVs substantially contributes to the … to J774 mice macrophages and A549
human lung epithelium cells … activate NLRP3 inflammasome [30]. In addition to the formation of …

[HTML][HTML] Cathelicidin-related antimicrobial peptide contributes to host immune responses against pulmonary infection with Acinetobacter baumannii in mice

MJ Kang, AR Jang, JY Park, JH Ahn, TS Lee… - Immune …, 2020 - ncbi.nlm.nih.gov
… how the innate immune response mediates the resistance of … of innate immune cells in CRAMP
−/− mice than in WT mice. In … baumannii in neutrophils by inhibiting NLRP3 inflammasome

Inflammasome activation in acute lung injury

MJ McVey, BE Steinberg… - … -Lung Cellular and …, 2021 - journals.physiology.org
… suppression of NLRP3 inflammasome activation by IL-4 has also … NLRP3-mediated
inflammasome signaling contributes to … , but not NLRP3 inflammasome-knockout mice, …

Effect of Tocilizumab on Acinetobacter baumannii Lung Infection in an Immunosuppressed Rat Model

D Celebi, Z Halici, O Celebi, N Akgun… - Kafkas Üniversitesi …, 2022 - vetdergikafkas.org
… infection in immunosuppressed rats. A forty-eight female … responses which leads to the
production of proinflammatory … baumannii infections in patients with a weak immune system […

Identification of two variants of Acinetobacter baumannii strain ATCC 17978 with distinct genotypes and phenotypes

CDM Wijers, L Pham, S Menon, KL Boyd… - … and Immunity, 2021 - Am Soc Microbiol
… increased neutrophilic lung inflammation in a mouse model of … gene contributes to bacterial
resistance to cell envelope … of the NLRP3 inflammasome resulting in the production of IL-1β, …

Inhibition of sphingosine-1-phosphate receptor 3 suppresses ATP-induced NLRP3 inflammasome activation in macrophages via TWIK2-mediated potassium efflux

Y Wang, C Wang, Q He, G Chen, J Yu, J Cang… - Frontiers in …, 2023 - frontiersin.org
Interleukin- (IL-1β) in the cell culture supernatant was detected … the survival and lung
vascular leakage in mice with cecal … sepsis, contributing to systemic inflammation and secondary …